What Is Genetic Testing?

With the process of In Vitro Fertilization (IVF), we can fertilize the egg with sperm and produce embryos. The embryos are cultured in a laboratory for 5-6 days as they develop into the blastocyst stage, after which an embryo biopsy is performed. The embryologist performs an embryo biopsy using a laser under the control of an inverted microscope. At AFCT, the embryo biopsy is performed personally by Dr. Dmitri Dozortsev, a President of the American College of Embryology who was one of the pioneers and the developer of the embryo biopsy techniques at the Reproductive Genetics Institute in Chicago.

Dr. Dozortsev continues to innovate by creating new tools improving embryo biopsy, such as ENVETM holder and VitroholderTM (www.invitrolife.com).

Recently Dr. Dozortsev developed a new method for embryo biopsy, Minimal Impact BiopsyTM , which increases safety of the embryo during the procedure. http://ivfconundrums.com/reproductive-laboratory/minimal-impact-biopsy-human-embryo-mib-dr-dmitri-dozortsev

He prepares a set of custom-made microtools for each embryo biopsy to maximize its safety and effectiveness.

The biopsy material is sent for testing by a courier, while embryos are frozen awaiting for the results from the test.

Studies have shown that close to 50% of embryos, even from the best patients, can be abnormal. The proportion of abnormal embryos increases with woman’s age (usually after the age of 35, with a more dramatic increase in abnormality after the age of 40).

The vast majority of chromosomal errors are called de novo random errors, meaning the patient has no predisposition to any particular type of error or family genetic transmission. The visual appearance of chromosomally abnormal embryos will appear completely normal to an embryologist but will fail to implant, end up in a miscarriage, or develop a child with chromosomal abnormalities.

 

Types of Genetic Testing