PGD and Gender selection

PGD is a laboratory technique used in patients undergoing in vitro fertilization (IVF). It allows the embryologist to look for chromosome or genetic problems with the embryo. Chromosomal problems of the embryos include an abnormal number of chromosomes, loss of portions of a chromosome or attachment of one piece of a chromosome to another chromosome. Genetic problems include problems with the genes of the embryo such as inherited conditions which run in families.

PGD is performed by removing one or two of the eight cells (blastocyst biopsy) from an embryo on day 3 after the egg retrieval or, some times at the blastocyst stage on day 5.

The cell is analyzed for chromosome number or genetic problems in the next 1-2 days. If the tests on the cell(s) are normal, the embryo can be transferred to the uterus of the patient on day 5 after egg retrieval.

At the Advanced Fertility Center of Texas, Same Day PGD™ allows patients to have their embryos tested on day 3 without the need for extended embryo culture (culture to day 5). An advanced FDA approved laser called Zilos-tk is used in the perform the biopsy. Analysis of chromosomes X, Y, and chromosome 21 is performed within hours at our on-site laboratory. Analysis of these chromosomes covers the vast majority of chromosomal aberrations seen in newborns. Same Day PGD™ allows us to transfer better quality embryos and improve the implantation and pregnancy rates.

In cases one or both partners are known to have abnormal genes or inherited conditions, we collaborate with the Reproductive Genetics Institute in Chicago and Dr. Mark Hughes in Detroit, both world leaders in single gene disorders. PGD in these cases will be preformed on day 3; the embryo biopsied will be tested for up to twelve chromosomal aberrations as well as known translocations and single gene disorders. For these cases, the result will be obtained in 48 hours and the embryos will be transferred on day 5.

The removal of the cell(s) does not induce any abnormalities of the future baby, however, it may decrease a chance of the embryo to become a baby.

Therefore, at our center we are very selective about offering PGD and carefully consult every patient regarding the procedure and its benefits and risks. 

Learn more about PGD at www.pgdupdate.com